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Taming the Piers-Rubinsztajn Reaction: Beyond B(C6F5)3

Development of the “Phase Separation” Strategy: Addressing Dilution Effects in Macrocyclization
S. K. Collins*, A.-C. Bédard, É. Godin, M. Raymond, M. de Léséleuc, S. Parisien-Collette, S. Régnier, J. Santandrea, and M. Holtz-Mulholland Canadian Journal of Chemistry 2025, 103, 465-479
Reconfigurable system for automated optimization of diverse chemical reactions

A.-C. Bédard, A. Adamo, K. C. Aroh, M. G. Russell, A. A. Bedermann, J. Torosian, B. Yue, K. F. Jensen*, T. F. Jamison* Science 2018, 361, 1220-1225.

H. Seo, A.-C. Bédard, W. P. Chen, R. W. Hicklin, A. Alabugin, T. F. Jamison* Tetrahedron, 2018, 74, 3124-3128.
Selective
N-monomethylation of primary anilines with dimethyl carbonate in continuous flow
Phase Separation Macrocyclization in a Complex Pharmaceutical Setting: Application toward the Synthesis of Vaniprevir

E. Godin, A.-C. Bédard, M. Raymond and S. K. Collins* Journal of Organic Chemistry, 2017, 82, 7576‑7582.

Minimizing E-factor in the continuous-flow synthesis of diazepam and atropine
A.-C. Bédard, A R. Longstreet, J. Britton, Y. Wang, H. Moriguchi, R. W. Hicklin, W. H. Green and T. F. Jamison* Bioorganic & Medicinal Chemistry 2017, 25, 6233–6241.
Efficient Continuous-Flow Synthesis of Macrocyclic Triazoles

A.-C. Bédard, J. Santandrea and S. K. Collins*
Journal of Flow Chemistry, 2015, 5, 142‑144.





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